Recent technological advances enabled high-throughput collection of Small Angle X-ray Scattering (SAXS) profiles\r\nof biological macromolecules. Thus, computational methods for integrating SAXS profiles into structural modeling\r\nare needed more than ever. Here, we review specifically the use of SAXS profiles for the structural modeling of\r\nproteins, nucleic acids, and their complexes. First, the approaches for computing theoretical SAXS profiles from\r\nstructures are presented. Second, computational methods for predicting protein structures, dynamics of proteins in\r\nsolution, and assembly structures are covered. Third, we discuss the use of SAXS profiles in integrative structure\r\nmodeling approaches that depend simultaneously on several data types.
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